Gas Chromatography-mass spectrometry is often used for metabolomics applications because of its reproducibility and chromatographic resolution power. However, many of the target metabolites (e.g. organic acids, amino acids, carbohydrates) would not be suitable for GC chromatographic analysis due to their physical and chemical properties. Hence, a chemical derivatisation prior to analysis is often required to increase their volatility and thermal stability and allow their successful detection.
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Automation of Derivatisation Workflows for GC-MS Metabolomics Applications