Thanks to increases in sensitivity of instrumental platforms, sample sizes can be easily scaled down while achieving required detection limits. This application note compares performances of the Agilent 5977B GC-MSD and 7250 GC-Q-TOF for the analysis of environmental contaminants using automated Dispersive Liquid Liquid Microextraction (DiLLME). Targeted and untargeted work using QTOF data gives higher confidence in results thanks to the accurate mass data, achieving mass accuracy less than 5ppm. In combination with MS/ MS and Low Energy Electron Ionisation (LE_EI) capabilities, the Q-TOF is a very powerful tool for structural interrogation and confirmation.
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Comparison on the Agilent 5977B MSD with High Efficiency Source and 7250 Q-TOF for Analysis using DLLME of Semi Volatile Organic Compounds