Large Volume Injection (LVI) is a very powerful technique that allows you to overcome the struggles of low limits of detections in gas chromatography trace analysis. In fact, LVI allows significantly larger injection volumes (typically 10 µL to 100 µL), depending on the injection solvent and application. However, developing the correct injection parameters can be time-consuming. By using the Automated Liner Exchange (ALEX) option on the GERSTEL MPS and a Design of Experiment (DoE) approach, it was possible to efficiently determin the optimum conditions for LVI of organic contaminants in water.
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Optimisation of a Large Volume Injection (LVI) Method for Organic Contaminants in Water Using Design of Experiments (DoE)